Pharmacogenomics Essay - 12639 Words - StudyMode.
Pharmacogenomics in the Future of Health Care Practice Abstract: Pharmacogenomics is an up and coming technology that encompasses the areas of health care, science, drug therapy and genetics. Pharmacogenomics research examines gene expression, and how drugs can be best suited to work with an individual's DNA sequence.
Pharmacogenomics combines traditional pharmaceutical sciences such as biochemistry with annotated knowledge of genes, proteins, and single nucleotide polymorphisms (Human Genome Project Information, 2011). The field of pharmacogenomics is still in its infancy. Its use is currently quite limited, but new approaches are under study in clinical trials.
This review focuses first on the concept of pharmacogenomics and its related concepts (biomarkers and personalized prescription). Next, the first generation of five pharmacogenomic tests used as diagnostic tests in the clinical practice of psychiatry is briefly reviewed.
Genomic medicine, which uses DNA variation to individualise and improve human health, is the subject of this Series of papers. The idea that genetic variation can be used to individualise drug therapy—the topic addressed here—is often viewed as within reach for genomic medicine. We have reviewed general mechanisms underlying variability in drug action, the role of genetic variation in.
Free Essay: Pharmacogenomics of Sickle Cell Disease Abstract Hydroxyurea is a treatment therapy that is currently used to treat sickle cell disease. There.
History Pharmacogenetics was first discovered in the 1950’s, however it was used to isolate how genes affected the metabolizing of drugs.When pharmacogenetics was first started, they did not have the aid of the technology we do today, so the doctors of the 1950’s discovered how genes affected drugs by testing how people of different ethnicities reacted to drugs, and they would record how.
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Classical approaches in pharmacogenomics involved genotyping of a predefined panel of a selected number of functionally characterized variants. However, the predefined panel approach was mainly applicable to common variants and may not identify or classify rare variants; broader approaches such.
Pharmacogenomics combines conventional pharmaceutical sciences such as biochemistry with understanding of genes, proteins, and single nucleotide polymorphisms. By doing so, pharmacogenomics aims to optimize drug therapy, with respect to the patients' genotype, which would result in maximum effectiveness and minimum side effects.
Essay text: The pathbreaking Mayo Clinic research into pharmacogenomics not only explained this phenomenon, it also led to the development of thiopurine prescriptions that are tailored to the genetic makeup of an individual child - a standard approach at Mayo since 1991.
An introduction to pharmacogenomics We know that people respond differently to medicines. While most people respond well and gain the intended effects, others do not benefit. Similarly, all drugs have side effects, but some people are more likely to suffer these than others. These differences in drug response are determined, in part, by our genes.
Pharmacogenomics is the study of variation of humans genomes and how they are affected by a response to medications, due to heredity, that would be tailor-made to adapt to a person or population genetic make up to lessen drug caused morbidity.
Prior to 1995, there were essentially no papers in the literature that focused on hypertension pharmacogenomics. There were studies focused on drug-metabolizing enzymes, and, as it relates to antihypertensive drugs, the most important was the cytochrome P4502D6 enzyme, which has numerous common genetic polymorphisms, some of which lead to absence of functional protein.
